We also encourage the submission of manuscripts presenting preclinical and very preliminary research that may stimulate further investigation of potentially relevant findings, as well as in-depth review articles on specific therapies or disease states, and applied health delivery or pharmacoeconomics.CTR encourages and supports the submission of manuscripts describing: Interventions designed to understand or improve human health, disease treatment or disease prevention; Studies that focus on problems that are uncommon in resource-rich countries; Research that is "under-published" because of limited access to monetary resources such as English language support and Open Access fees (CTR offers deeply discounted English language editing); Republication of articles previously published in non-English journals (eg, evidence-based guidelines) which could be useful if translated into English; Preclinical and clinical product development studies that are not pursued for further investigation based upon early phase results.