PRL covers the full range of applied, fundamental, and interdisciplinary physics research topics:General physics, including statistical and quantum mechanics and quantum informationGravitation, astrophysics, and cosmologyElementary particles and fieldsNuclear physicsAtomic, molecular, and optical physicsNonlinear dynamics, fluid dynamics, and classical opticsPlasma and beam physicsCondensed matter and materials physicsPolymers, soft matter, biological, climate and interdisciplinary physics, including networks