Science Immunology will publish original, peer-reviewed, science-based research articles that report critical advances in all areas of immunological research, including important new tools and techniques. The editors encourage submission of original research findings from all areas within the broad field of immunology from all model organisms, including humans. Areas covered range from basic studies into the biology of innate and adaptive immunity (immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology) to immune contributions to health and disease (host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency). The editors and an international advisory group of scientists will hold Science Immunology articles to the same high-quality standard that is the hallmark of the Science family of journals.