The journal is particularly interested in studies on the design and synthesis of new genetic circuits and gene products; computational methods in the design of systems; and integrative applied approaches to understanding disease and metabolism.Topics may include, but are not limited to:Design and optimization of genetic systemsGenetic circuit design and their principles for their organization into programsComputational methods to aid the design of genetic systemsExperimental methods to quantify genetic parts, circuits, and metabolic fluxesGenetic parts libraries: their creation, analysis, and ontological representationProtein engineering including computational designMetabolic engineering and cellular manufacturing, including biomass conversionNatural product access, engineering, and productionCreative and innovative applications of cellular programmingMedical applications, tissue engineering, and the programming of therapeutic cellsMinimal cell design and constructionGenomics and genome replacement strategiesViral engineeringAutomated and robotic assembly platforms for synthetic biologyDNA synthesis methodologiesMetagenomics and synthetic metagenomic analysisBioinformatics applied to gene discovery, chemoinformatics, and pathway constructionGene optimizationMethods for genome-scale measurements of transcription and metabolomicsSystems biology and methods to integrate multiple data sourcesin vitro and cell-free synthetic biology and molecular programmingNucleic acid engineering.