Formerly the IMA Journal of Mathematics Applied in Medicine and Biology.Mathematical Medicine and Biology publishes original articles with a significant mathematical content addressing topics in medicine and biology. Papers exploiting modern developments in applied mathematics are particularly welcome. The biomedical relevance of mathematical models should be demonstrated clearly and validation by comparison against experiment is strongly encouraged.The journal welcomes contributions relevant to any area of the life sciences including:-biomechanics-biophysics-cell biology-developmental biology-ecology and the environment-epidemiology-immunology-infectious diseases-neuroscience-pharmacology-physiology-population biology