Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defence mechanisms. Immunologists attempt to understand how the immune system develops, how the body defends itself against disease, and what happens when it all goes wrong. Nature Reviews Immunology provides in-depth coverage of all areas of immunology, from fundamental mechanisms to applied aspects. Subjects Covered:-Allergy and asthma-Autoimmunity-Antigen processing and presentation-Apoptosis and cell death-Chemokines and chemokine receptors-Cytokines and cytokine receptors-Development and function of cells of the immune system-Haematopoiesis-Infection and immunity-Immunotherapy-Innate immunity-Mucosal immunology and the microbiota-Regulation of the immune response-Signalling in the immune system-Transplantation-Tumour immunology and immunotherapy-Vaccine development